Neurovirological Correlation With HIV-Associated Neurocognitive Disorders and Encephalitis in a HAART-Era Cohort
04/2013
Journal Article
Authors:
Gelman, B.;
Lisinicchia, J.;
Morgello, S.;
Masliah, E.;
Commins, D.;
Achim, C.;
Fox, H.;
Kolson, D.;
Grant, I.;
Singer, E.;
Yiannoutsos, C.;
Sherman, S.;
Gensler, G.;
Moore, D.;
Chen, T.;
Soukup, V.
Secondary:
J Acquir Immune Defic Syndr
Volume:
62
Pagination:
487-495
URL:
http://www.ncbi.nlm.nih.gov/pubmed/23242157
Keywords:
dementia; encephalitis; HAND; HIVE; interferon; neurocognitive disorders
Abstract:
{OBJECTIVE:: Replicating HIV-1 in the brain is present in HIV encephalitis (HIVE) and microglial nodule encephalitis (MGNE) and is putatively linked with HIV-associated neurocognitive disorders (HAND). A clinico-neurovirological correlation was conducted to elucidate the relationship between brain viral load and clinical phenotype. SUBJECTS: and assays: HIV gag/pol RNA and DNA copies were quantified with RT-PCR or PCR in 148 HAART-era brain specimens. Comparison to HAND, HIVE and MGNE and correlation with neuropsychological (NP) test scores were done using one-way ANOVA with Tukey-Kramer and Spearman's tests respectively. RESULTS:: Brain HIV RNA was higher in subjects with HAND plus HIVE vs without HAND (delta = 2.48 log10 units
