Mismatched Related and Unrelated Donors for Allogeneic Hematopoietic Cell Transplantation for Adults with Hematologic Malignancies
10/2014
Journal Article
Authors:
Eapen, M.;
O'Donnell, P.;
Brunstein, C.G.;
Wu, J.;
Barowski, K.;
Mendizabal, A.;
Fuchs, E.J.
Secondary:
Biol Blood Marrow Transplant
Volume:
20
Pagination:
1485-1492
URL:
http://www.ncbi.nlm.nih.gov/pubmed/24862638
Keywords:
Alternative donor transplantation; Donor selection algorithm; Hematologic malignancy
Abstract:
Two parallel phase II trials in adults with hematologic malignancies demonstrated comparable survival after reduced-intensity conditioning and transplantation of either 2 HLA-mismatched umbilical cord blood (UCB) units or bone marrow from HLA-haploidentical relatives. Donor choice is often subject to physician practice and institutional preference. Despite clear preliminary evidence of equipoise between HLA-haploidentical related donor and double unrelated donor UCB transplantation, the actual prospect of being randomized between these 2 very different donor sources is daunting to patients and their treating physicians alike. Under these circumstances, it is challenging to conduct a phase III randomized trial in which patients are assigned to the UCB or haploidentical bone marrow arms. Therefore, we aimed to provide an evidence-based review and recommendations for selecting donors for adults without an HLA-matched sibling or an HLA-matched adult unrelated donor.
